Damian Sendler: As of December of this year, the world has been dealing with the COVID-19 pandemic, which has been one of the most shocking outbreaks in human history.
Respiratory droplets and direct touch were found to be the primary modes of transmission of COVID-19. High amounts of IL-2, IL-7, IL-10, GSH, IP10, MCP1, MIP1A, and TNF were seen in patients in intensive care units (ICUs).
Due to the disease’s three-stage clinical course, inadequate innate immune response in the first stage and immuno-mediated damage due to dysregulated immune response in the second stage are regarded to be the main drivers of poor outcomes.
Damian Sendler
According to emerging evidence from patients about the natural history and progression of the illness, several medication classes and supplements, including vitamin D, are being explored for treatment of COVID-19.
Damien Sendler: Many cell processes are regulated by the secosteroid hormone, vitamin D, which has been on the planet for 750 million years. It is converted to the physiologically active 1,25-dihydroxyvitamin D in the liver and kidneys after being created in the skin by sunshine or dietary intake.
Vitamin D’s skeletal and bone metabolic effects have been widely known for a long time, but its extra-skeletal effects have only recently risen to prominence. In addition, it has a significant impact on the regulation of the immunological response, oxidative stress, cancer biology, and the neurological system.
Tuberculosis was treated with vitamin D prior to the introduction of anti-mycobacterial medicines. Vitamin D insufficiency has been linked to higher incidence or severity of many diseases, such as influenza, bacterial vaginosis, and human immunodeficiency virus infection. Recently, the role of vitamin D in regulating the immune response and mitigating the course of acute infections has been discussed .
ICU infection-related mortality may be reduced by raising hemoglobin concentrations, lowering serum hepcidin concentrations, boosting oxygenation on the cell level, and reversing lung damage with vitamin D3 supplementation .
An connection between vitamin D deficiency and higher mortality in COVID-19 has recently been discovered by researchers. More severe clinical variants of COVID-19 have been linked to vitamin D insufficiency . Supplementing with 10,000 IU/daily vitamin D in COVID-19 resulted in less symptoms for patients than those who did not supplement .
Dr. Damian Jacob Sendler and his media team provided the content for this article.
